Zepbound vs Semaglutide GLP-1 vs Wegovy: What’s the Difference?
Dr. Shima Hadidchi MD carefully considers various aspects to determine which weight loss medication is best for you. To find which medication is best, you will need to schedule a consultation appointment. During this session, the doctor will discuss your medical history and weight loss goals to develop a weight management plan that suits your needs and preferences. Contact us for more information. We have convenient locations to serve you in Apple Valley, CA and Victorville, CA.


Table of Contents:
What is Zepbound?
What’s the difference between Ozempic, Mounjaro, Wegovy, and Zepbound?
Which one is better for weight loss?
Does insurance cover these weight loss medications?
Zepbound is a weight loss medication that has recently gained FDA approval. It is an injectable, prescription drug that is highly effective at helping you shed unwanted pounds. Zepbound is intended to be used as part of a comprehensive weight loss plan for people with:
A body mass index (BMI) of 27 or higher along with the presence of at least one weight-related condition, such as high blood pressure, high cholesterol, sleep apnea, or type 2 diabetes, or A BMI of 30 or higher.
If you fall into the above criteria and think Zepbound can provide you with a boost on your weight loss journey, you’ll need to speak with a physician to determine if this medication is right for you. Zepbound’s active ingredient is Tirzepatide, which has a dual-hormone action to support your weight loss efforts. The medication targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors to deliver its effects. Through this mechanism of action, Zepbound regulates appetite and slows gastric emptying to help you feel fuller for longer.
Distinguishing between Ozempic, Wegovy, Mounjaro, and Zepbound can get confusing. While Wegovy and Zepbound are approved for weight loss purposes, Ozempic and Mounjaro are primarily approved for the treatment of type 2 diabetes. However, Ozempic and Mounjaro are occasionally prescribed for weight loss treatment off-label, so all four medications are used for similar purposes.
Ozempic and Wegovy are manufactured by Novo Nordisk and both contain Semaglutide GLP-1 as their active ingredient. On the other hand, Mounjaro and Zepbound are manufactured by Eli Lilly and contain Tirzepatide. While Semaglutide GLP-1 and Tirzepatide have similar mechanisms of action, Semaglutide GLP-1 only mimics the action of one gut hormone. As Tirzepatide acts on two hormone receptors, it is believed to be slightly more effective than Semaglutide GLP-1. This suspicion was confirmed in a 2023 study, and additional research is currently ongoing.
Overall, while there are differences between Ozempic, Munjaro, Wegovy, and Zepbound, these medications have many similarities as well. To determine which option is recommended for you, schedule a consultation with a doctor specializing in weight loss.
As Zepbound and Wegovy are FDA-approved for weight loss and management, they are considered the best options out of all of the Semaglutide GLP-1 and Tirzepatide formulations available. Tirzepatide medications, such as Zepbound, can be delivered in higher dosages. Due to this, Zepbound is considered to be the most effective weight loss medication currently on the market.
Doctors carefully consider various aspects to determine which weight loss medication is best for you. To find which medication is best, you will need to schedule a consultation appointment. During this session, the doctor will discuss your medical history and weight loss goals to develop a weight management plan that suits your needs and preferences.
It’s crucial to keep in mind that with any weight loss medication, you’ll need to commit to a healthy lifestyle to observe the most desirable results. By exercising regularly, eating a balanced diet, hydrating well, and sleeping enough, you can reach your weight and wellness goals with medication and a healthcare professional’s guidance.
While Zepbound, Wegovy, Ozempic, and Mounjaro are incredible tools for treating obesity and excess weight, many insurance providers do not offer sufficient coverage for these medications. Some health plans cover certain medications under specific circumstances, so it’s best to double-check with your insurance company to be aware of what your out-of-pocket costs will be.
Our clinic accepts most major insurance plans, such as Aetna, Medicaid, Cigna, Tricare, and Healthnet. Our team can help you determine whether your plan covers your weight loss treatment. If not, we offer affordable self-pay rates. In addition, the manufacturers of these medications offer savings programs and discounts to make treatment more accessible to those who need it. If you have any questions, our staff is here to support you and help you get clarity. Contact us for more information. We have convenient locations to serve you in Apple Valley, CA and Victorville, CA. We serve patients from Victorville CA, Apple Valley CA, Adelanto CA, Hesperia CA, Crestline CA, Highland CA, Barstow CA, and BEYOND!

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